What is the most significant and enduring legacy of America’s struggle with slavery from Jamestown to the Civil War? 3 page essay on the most significant and enduring legacy of America’s struggles with slavery from Jamestown to the Civil War. You can only use class materials (lecture, readings, and videos) as sources in the paper. No outside sources are allowed for this paper. Failure to submit the essay on time will result in a zero and a lower semester attendance and participation grade.